Comorbidities in severe asthma are common, they complicate management and effect patient outcome. Comorbidities may frequently interact, contribute to poor disease control and mimic symptoms of asthma. They may also increase the cost of treatment for people with severe asthma and lead to overtreatment. It is therefore recommended that comorbidities be addressed in severe asthma (Chung et al. 2014). Multidimensional assessment of severe asthma allows for the recognition of these comorbidities and has been shown to improve patient outcomes (Clark et al. 2017). In this module, we deal with the most common comorbidities associated with severe asthma, we present their prevalence and impact and provide recommendations for assessment and management.